Prof. Swathi Sudhakar
Dept of Applied Mechanics and Biomedical Engineering
Prof. Swathi Sudhakar
Research Areas
Dept of Applied Mechanics and Biomedical Engineering
People
Phd Scholars
Kaviya V B - Ph.D. scholar
Thilak Raj K – Ph.D. scholar
Anagha Manohar – Ph.D. scholar
Narendren S - Ph.D. scholar
Post Doc
Dr. Abirami - Post Doc
Gopikasri M – MS scholar
Shubham Chakraborty – MS scholar
Anisha Kabir – Project Associate
Research
- Investigation of particle shape effects in colloidal systems: Evaporation driven self-assembly, Colloids at interfaces, Pickering emulsions
- Structure and rheology colloids, wax-oil mixtures and polymer-ionic liquid solutions
- Dessication cracks – effect of particle shape and external fields.
- Hetero-aggregation in colloidal systems: applications in interfacial science
- New materials and particles: functional materials using interfacial templates, synthesis and self-assembly of patchy colloids
- Interfacial spreading – statics and kinetics
- Emulsion fuels – formulation and engine studies
- Image processing and analysis – Applications in particle science and medicine.
Projects
Exploring Nanotherapeutics for Disease Treatment and Biomedical Applications
- Numerous novel approaches are emerging to overcome the limitations of conventional cancer treatment, such as chemotherapy, surgery, and radiotherapy.
- Nanotechnology in cancer treatment has emerged as an effective drug carrier system and the function of targeted drug delivery system aid in delivering drug molecule that specifically binds with proteins and induces apoptosis.
- Different types of nanoparticles have been studied as drug delivery systems but still lack effective drug loading efficiency, biocompatibility, high cytotoxicity, and internalization of the nanoparticle by cancer cells
- To overcome the limitations of nanoparticles as drug carriers, hematite nanoparticles are introduced in this study to fulfill the limitation caused by other nanoparticles as drug delivery systems.
Gold nanoparticles (AuNPs) entrapped by nano-lipid
SEM images
Hematite nanoparticles - spherical shape
Hematite nanoparticles - ellipsoidal shape
Design and Development of Advanced Biosensors for Early Detection of Cancer
- The aim of early cancer diagnosis is to identify individuals at their early stage of cancer, as soon as possible to give them the best chance survival.
- A lower chance of survival, more treatment-related issues, and higher cost of care are all consequences of delayed or inaccessible cancer therapy.
- For delivering care at the earliest possible stage so as to increase chance of recovery, early diagnosis is inevitable.
- In malignant cells, glutamine has a role in energy production, redox balance, macromolecular synthesis, and signaling. It is an abundant and essential nutrient, due to these qualities, glutamine levels and its metabolism is a desirable target for novel clinical approaches to diagnose, monitor, and treat cancer.
- So, the research aim is to develop portable, optical biosensor to detect the L-glutamine levels in individuals, so to detect the cancer in its early stage for higher chance of survival.
Temporal response of Direct assay with L-glutamine(50µg/mL)
Anti-glutamine(2.5µg/mL) conjugated with AuNP
Spectra substantiates
L-glutamine, anti-glutamine binds with high affinity
Studying Phase separation in biological systems
- Liquid-liquid phase separation (LLPS) occurs when macromolecules and the solvent demix into condensed and dilute phases, forming liquid droplets.
- Several proteins that can undergo LLPS physiologically are also found in pathological protein aggregates.
- These aggregates are hallmarks of neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s Disease, and so on.
- In malignant cells, glutamine has a role in energy production, redox balance, macromolecular synthesis, and signaling. It is an abundant and essential nutrient, due to these qualities, glutamine levels and its metabolism is a desirable target for novel clinical approaches to diagnose, monitor, and treat cancer.
- So, the research aim is to develop portable, optical biosensor to detect the L-glutamine levels in individuals, so to detect the cancer in its early stage for higher chance of survival.
Temporal response of Direct assay with L-glutamine(50µg/mL)
Anti-glutamine(2.5µg/mL) conjugated with AuNP
SEM images
Fluorescence microscopic image
Protein-based Active Colloids
- Active colloids have been the most researched area in soft condensed matter in recent times due to their ability to replicate biomimetic motions.
- Our research interest lies in studying the kinetics of self-propelling protein-based colloidal particles in a fluid medium and their application in targeted drug delivery.
Temporal response of Direct assay with L-glutamine(50µg/mL)
Anti-glutamine(2.5µg/mL) conjugated with AuNP
Nanoparticle for agricultural applications
- Fungal diseases in agriculture are a source of concern for crop production.
- Synthetic fungicides are used to protect crops, but they pollute the environment because only a small portion is absorbed by plants.
- To address this, we synthesized hydroxyapatite (HA) nanoparticles with PEG and loaded the nanoparticles with surfactin, a potent bio-surfactant with antimicrobial properties, to enhance the dual function of fertilizer and fungicide.
SEM images showing the HA nanoparticles
Anti-microbial assay of drug loaded HAP
Development of therapeutic strategies to mitigate oxidative stress and cytoskeletal damage in astronauts for the Gaganyaan space mission
- The project aims to explore the relationship between exposure to microgravity and the development of oxidative stress in astronauts, leading to weakened bones and vasculature and as a result, osteoporosis.
- Based on the observations, nanotherapeutics would be developed to combat the stress conditions, which would enable the safer execution of manned space missions in the future.
- To address this, we synthesized hydroxyapatite (HA) nanoparticles with PEG and loaded the nanoparticles with surfactin, a potent bio-surfactant with antimicrobial properties, to enhance the dual function of fertilizer and fungicide.
TEM image of Luteolin-loaded Zein Nanoparticles
SEM image of Ascorbic acid loaded Zein Nanoparticles
Resolving the microtubule dynamics using single-molecule techniques and computer simulations
- The dynamics of cytoskeletal proteins decide the underlying mechanism of neurodegenerative diseases and malignancy observed in cancerous cells.
- This project aims to study about the interactions observed in microtubules at the molecular level using single molecule techniques alongside computer simulations which will help in designing targeted drug delivery approaches for such diseases.
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Collaboration
- Prof. Albert PHJ Schenning , TU Eindhoven, The Netherlands: https://www.tue.nl/en/
research/researchers/albert- schenning - Prof. Patrick Onck , University of Groningen, The Netherlands: https://www.rug.nl/
staff/p.r.onck/?lang=en
Social Impact
- content to be added
Publication
- 18-β-glycyrrhetinic acid-loaded polymeric nanoparticles attenuate cigarette smoke-induced markers of impaired antiviral response in vitro G De Rubis, KR Paudel, S Yeung, S Mohamad, S Sudhakar, SK Singh, … Pathology-Research and Practice 257, 155295 2024
- Effect of biopolymer concentration on the kinetics of marine snow formation TR Akshaya, S Sudhakar, E Mani, K Murali Deep Sea Research Part I: Oceanographic Research Papers 207, 104291 2024
- Charge-defect tuned PVDF based ternary biocompatible composite as skin touch actuated single electrode triboelectric nanogenerator for wireless healthcare monitoring A Sasmal, A Seetharaman, P Maiti, S Sudhakar, A Arockiarajan Chemical Engineering Journal 487, 150573 2024
- Chitosan derived chito-oligosaccharides promote osteoblast differentiation and offer anti-osteoporotic potential: Molecular and morphological evidence from a zebrafish model S Vimalraj, D Govindarajan, S Sudhakar, R Suresh, P Palanivel, … International Journal of Biological Macromolecules 259, 129250 2024
- Enhancing precision and efficiency: harnessing robotics and artificial intelligence for endoscopic and surgical advancements V Selvaraj, S Sudhakar, S Sekaran, SKR Sekar, S Warrier International Journal of Surgery 110 (2), 1315-1316 2 2024
- Elucidating shape mediated drug carrier mechanics of Hematite Nanomaterials on Breast Cancer therapeutics KV Babunagappan, T Raj, A Seetharaman, S Ariraman, S Sudhakar Journal of Materials Chemistry B 2024
- Doxorubicin loaded thermostable nanoarchaeosomes: a next-generation drug carrier for breast cancer therapeutics KV Babunagappan, A Seetharaman, S Ariraman, PB Santhosh, J Genova, … Nanoscale Advances 2024
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